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Green light‐emitting diode phototherapy for neonatal hyperbilirubinemia: Randomized controlled trial
Author(s) -
Kuboi Toru,
Kusaka Takashi,
Okada Hitoshi,
Arioka Makoto,
Nii Kohichiroh,
Takahashi Megumi,
Yamato Satoshi,
Sadamura Takaaki,
Jinnai Wataru,
Nakano Akiko,
Itoh Susumu
Publication year - 2019
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13821
Subject(s) - medicine , randomized controlled trial , bilirubin , blue light , serum bilirubin , significant difference , clinical trial , gastroenterology , optics , physics
Background The main photochemical pathway in phototherapy for neonatal hyperbilirubinemia is the production and elimination (in bile or urine) of cyclobilirubin, which is a structural photoisomer of bilirubin, and which is most efficiently produced by green light. Green light‐emitting diode ( LED ) phototherapy, however, has not been evaluated in the clinical setting because it is not recommended in American Academy of Pediatrics guidelines. We therefore compared the efficacy of green LED phototherapy and blue LED phototherapy in patients with neonatal hyperbilirubinemia. Methods In this prospective randomized controlled trial, neonates with hyperbilirubinemia were randomly allocated to a green LED or blue LED phototherapy group. Both groups underwent 24 h of phototherapy, and blood was sampled before and after 24 h of phototherapy. Total serum bilirubin ( TSB ) was measured using enzymatic methods and bilirubin photoisomers were measured on high‐performance liquid chromatography. Results Thirty‐four infants were randomized (green, n = 16; blue, n = 18). TSB decreased significantly from 15.3 ± 1.5 to 13.9 ± 1.5 mg/ dL in the green LED group ( P < 0.01) and from 16.2 ± 1.3 to 14.5 ± 1.7 mg/ dL in the blue LED group ( P < 0.01) after 24 h of phototherapy. No significant difference was found in TSB reduction after phototherapy between the groups. Conclusions Both light sources produced a significant reduction in TSB , indicating clinical effectiveness.