Premium
Down syndrome and mild kidney dysfunction
Author(s) -
Yamakawa Satoshi,
Nagai Takuhito,
Uemura Osamu
Publication year - 2018
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13525
Subject(s) - medicine , renal function , cystatin c , kidney , creatinine , cohort , urology , gastroenterology , endocrinology
Few studies have evaluated kidney function in children with Down syndrome ( DS ) in detail. This study investigated kidney function in pediatric DS patients without complications that affect kidney function. Creatinine (Cr)‐ and cystatin C (cysC)‐based estimated glomerular filtration rate ( eGFR ) were measured in a cohort of Japanese DS patients. The kidney function in these children with DS was approximately 80% that of the healthy Japanese children, suggesting that children with DS have smaller kidneys or a lower number of glomeruli than children without DS .