Down syndrome and mild kidney dysfunction

Few studies have evaluated kidney function in children with Down syndrome ( DS ) in detail. This study investigated kidney function in pediatric DS patients without complications that affect kidney function. Creatinine (Cr)‐ and cystatin C (cysC)‐based estimated glomerular filtration rate ( eGFR ) were measured in a cohort of Japanese DS patients. The kidney function in these children with DS was approximately 80% that of the healthy Japanese children, suggesting that children with DS have smaller kidneys or a lower number of glomeruli than children without DS .