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Influence of hypercholesterolemia on serum antibodies against oxidized LDL in children and adolescents
Author(s) -
Garoufi Anastasia,
Marmarinos Antonios,
Vraila VenetiaMaria,
Dimou Stamatina,
Pagoni Athanasia,
Vorre Styliani,
Paraskakis Irene,
Gourgiotis Dimitrios
Publication year - 2018
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13501
Subject(s) - medicine , antibody , apolipoprotein b , lipoprotein , endocrinology , low density lipoprotein , cholesterol , familial hypercholesterolemia , immunology
Background The oxidation of low‐density lipoprotein ( LDL ; ox LDL ) appears to play a key role in the early development of atherosclerosis. Increased serum antibodies against the ox LDL (anti‐ox LDL antibodies) have been found in adults with atherosclerotic disease, as well as in healthy adults. The clinical significance and its precise role (atherogenic or atheroprotective), however, have not yet been clarified. This aim of this study was therefore to evaluate anti‐ox LDL antibodies in healthy children and adolescents with and without hypercholesterolemia. Methods The study involved 312 subjects, aged 4–18 years, 141 with LDL cholesterol ( LDL ‐C) ≥130 mg/dL and 171 with acceptable LDL ‐C (<110 mg/dL). Total anti‐ox LDL antibodies, total cholesterol, LDL ‐C and high‐density lipoprotein cholesterol, triglycerides, apolipoproteins A1 and B, lipoprotein (a) and high‐sensitivity C‐reactive protein were measured in fasting serum. The anti‐ox LDL antibodies were measured on enzyme‐linked immunosorbent assay. Results Anti‐ox LDL antibodies were similar in the hypercholesterolemia and non‐hypercholesterolemia groups. Girls had significantly higher anti‐ox LDL antibodies compared with boys. There was no significant correlation of antibodies with age or body mass index. Increased apolipoprotein B was an important factor for lower anti‐ox LDL antibodies, while all other parameters had no significant association with anti‐ox LDL antibodies. Conclusion In children and adolescents with hypercholesterolemia, total anti‐ox LDL antibodies cannot serve as a marker for risk for atherosclerosis or for future cardiovascular disease.