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Prognostic factors in the early phase of acute encephalopathy
Author(s) -
Oba Chizu,
Kashiwagi Mitsuru,
Tanabe Takuya,
Nomura Shohei,
Ogino Motoko,
Matsuda Takuya,
Murata Shinya,
Nakamura Michiko,
Shirasu Akihiko,
Inoue Keisuke,
Okasora Keisuke,
Tamai Hiroshi
Publication year - 2018
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13492
Subject(s) - medicine , multivariate analysis , univariate analysis , status epilepticus , benzodiazepine , encephalopathy , lactate dehydrogenase , hepatic encephalopathy , disease , pediatrics , gastroenterology , epilepsy , cirrhosis , biochemistry , chemistry , receptor , psychiatry , enzyme
Background Neurological sequelae occur in 40% of patients with acute encephalopathy ( AE ). The early prediction of poor outcomes is critical to the initiation of appropriate treatment. The aim of the present study was therefore to elucidate prognostic factors that can be quickly and feasibly evaluated on hospital admission in patients with AE . Methods We analyzed data from 51 AE patients admitted to Hirakata City Hospital between January 2005 and December 2014. Age at onset, sex, underlying disease, status epilepticus ( SE ), presence of benzodiazepine‐resistant SE ( BZD ‐resistant SE ), and basic blood serum parameters on admission were evaluated in relation to each patient's outcome. Results On univariate analysis age at onset, BZD ‐resistant SE , and serum aspartate aminotransferase ( AST ), alanine aminotransferase, lactate dehydrogenase, and platelet count varied significantly according to outcome. On multivariate analysis age at onset (≤21 months), presence of BZD ‐resistant SE , and AST (≥46 IU /L) were identified as independent variables associated with poor outcome. Conclusion Age at onset, presence of BZD ‐resistant SE , and AST are associated with a poor prognosis in AE .