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Prevalence and characteristics of human parechovirus and enterovirus infection in febrile infants
Author(s) -
Sano Kentaro,
Hamada Hiromichi,
Hirose Shoko,
Sugiura Kenta,
Harada Satoko,
Koizumi Mai,
Hara Mayumi,
Nishijima Haruna,
Taira Masakatsu,
Ogura Atsushi,
Ogawa Tomoko,
Takanashi Junichi
Publication year - 2018
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13467
Subject(s) - medicine , enterovirus , virology , pediatrics , virus
Abstract Background Human parechovirus ( HP eV) and human non‐polio enterovirus ( EV ) are important causes of fever without source ( FWS ) in young infants. Their prevalence and clinical characteristics are largely unknown in Asian countries. This study was conducted to elucidate the epidemiology and clinical characteristics of HP eV and EV infection in febrile young infants in Japan. Methods During February 2010–August 2015, we obtained 53 stool, 44 throat swab, and 20 cerebrospinal fluid samples from 56 infants (<3 months) with FWS at a single hospital. To each sample, we applied reverse transcription–polymerase chain reaction for HP eV and EV . We compared the clinical characteristics of HP eV and EV patients. Results HP eV was detected in 11 and EV in 17 patients. HP eV was detected during July–September. HP eV patients, compared with EV patients, had lower age (32 vs 47 days; P = n.s.), higher prevalence of exclusive breast‐feeding (81.8 vs 29.4%; P = 0.024), and lower prevalence of sick contacts (36.4 vs 88.2%; P = 0.010). More HP eV than EV patients met the systemic inflammatory response syndrome criteria (90.9 vs 52.9%; P = 0.049). In the HP eV group, leukopenia, thrombopenia, and elevated deviation enzyme were observed, although the prevalence of abnormal cerebrospinal fluid was significantly lower than in the EV group. HP eV patients had longer hospital stay (7 vs 5 days; P = 0.025). Conclusion HP eV and EV are important causal viruses of FWS . Characteristic clinical pictures exist in these virus infections, but further research is needed to accumulate more cases to produce a comprehensive picture of these virus infections.