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Issue Information
Publication year - 2018
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13396
Subject(s) - germinal center , medicine , immunology , antigen , antibody , lymph , lamina propria , mesenteric lymph nodes , immune system , b cell , pathology , epithelium
(b) Common mucosal immune system for the induction of antibody‐specific IgA. M cells within the epithelial layer transportantigens from the lumen to APC, such as DC, which process and present antigens to CD4 + T cells. Stimulated T cells preferentially induce IgA‐committed B‐cell development in the germinal center. After classswitching to IgA production and affinity maturation, B cells rapidly migrate from PP to the regional mesenteric lymph nodes. Antigenspecific CD4+ T cells and IgA+ B cells migrate through the thoracic duct and blood circulation to reach the intestinal lamina propria, an effector site. IgA+ B cells and plasmablasts then differentiate into IgA‐producing plasma cells in the presence of cytokines, such as interleukin (IL)‐5 and IL‐6, which are produced by T‐helper 2 (Th2) cells. See Challenges in developing mucosal vaccines and antibodies against infectious diarrhea in children by Tokuhara in pages 214–223. Article link here