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Autonomic nervous system function in adolescent migraineurs
Author(s) -
Yoshida Seiji,
Tanaka Hidetaka,
Mizutani Midori,
Nakao Ryota,
Okamoto Naoyuki,
Kajiura Mitsugu,
Kanbara Yukiko,
Tamai Hiroshi
Publication year - 2017
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13342
Subject(s) - supine position , medicine , migraine , autonomic nervous system , heart rate variability , vasomotor , heart rate , cardiology , blood pressure , anesthesia
Abstract Background Migraine is a common and disabling neurological disorder. Studies on the relationship between migraine and the autonomic nervous system ( ANS ) have been inconclusive. Moreover, pediatric studies are extremely limited. Therefore, the present study investigated interictal ANS function in adolescent migraineurs. Methods We studied 21 patients with migraine and 26 healthy controls. Beat‐to‐beat blood pressure ( BP ) and heart rate ( HR ) were non‐invasively and continuously measured in the supine and standing positions. ANS function was evaluated on power spectral analysis of HR variability and diastolic BP ( DBP ) variability. Results Heart rate and systolic BP were not different between the two groups in either the supine or standing position. DBP did not differ between groups in the standing position, but was significantly higher in migraineurs in the supine position. The vasoconstrictor index was significantly higher in migraineurs. High‐frequency ( HF ) RR interval variability ( RR ‐ HF ) and the ratio of the low‐frequency ( LF ) to HF component of RR interval variability ( RR ‐ LF / HF ) were not different between the two groups in both positions. The LF component of DBP variability ( DBP ‐ LF ) in the supine position was significantly lower in migraineurs, while DBP ‐ LF during standing in migraineurs was significantly higher than in controls. Conclusion Migraineurs have significantly lower sympathetic vasomotor activity in the supine position, while sympathetic vasomotor activity was hyperresponsive during standing.