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Birthweight and serum uric acid in American adolescents
Author(s) -
Rhone Erika T.,
Carmody J. Bryan
Publication year - 2017
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13328
Subject(s) - medicine , uric acid , blood pressure , obesity , endocrinology , gastroenterology
Elevated serum uric acid is associated with hypertension and chronic kidney disease. We evaluated the relationship between birthweight and uric acid in a nationally representative sample of 5390 US adolescents aged 12–15 in the National Health and Nutrition Examination Survey from 1999 to 2012. There was an inverse association between birthweight and uric acid after adjustment for sex, age, race, obesity, and dietary sodium intake. Each 1 kg increase in birthweight was associated with decreased uric acid by 0.11 mg/ dL (95% CI : −0.16 to −0.06; model R 2 = 0.32). This relationship was stronger in adolescents with elevated blood pressure (β = –0.25; 95% CI : −0.44 to −0.06; R 2 = 0.50) but persisted in adolescents with normal blood pressure (β = –0.10; 95% CI : −0.15 to −0.05; R 2 = 0.31). In conclusion, lower birthweight is associated with higher uric acid in US adolescents. These findings may support the hypothesis that reduced nephron number is associated with elevated uric acid.