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Cellular and humoral immunity after vaccination or natural mumps infection
Author(s) -
Terada Kihei,
Hagihara Kimiko,
Oishi Tomohiro,
Miyata Ippei,
Akaike Hiroto,
Ogita Satoko,
Ohno Naoki,
Ouchi Kazunobu
Publication year - 2017
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13306
Subject(s) - medicine , vaccination , titer , antibody , immunology , immunity , antibody titer , immune system
Background This study measured cell‐mediated immunity ( CMI ) and serum antibody to clarify the basis of breakthrough after vaccination and reinfection after mumps. Methods From a pool of 54 college students, 17 seronegative subjects and 14 subjects with intermediate level of antibodies against mumps were vaccinated with a monovalent mumps vaccine, and CMI was assessed using interferon‐γ release assay. Results CMI positivity according to pre‐existing antibody level, defined as titer <2.0 index units, negative; 2.0–3.9 index units, intermediate; and ≥4.0 index units, positive, was 8/17 (47.1%), 9/14 (64.3%) and 19/23 (82.6%) before vaccination, respectively. Of the 17 seronegative subjects, seven (41.2%) had a history of vaccination and/or natural infection, four (57.1%) of whom were CMI positive or intermediate. Ten (71%) of 14 subjects with intermediate antibody level had a history of vaccination or natural infection, eight (80%) of whom were CMI positive or intermediate. After vaccination the interferon ( IFN )‐γ and antibody titers increased significantly, but seven (41.2%) of the 17 seronegative subjects and 13 (92.9%) of the 14 intermediate‐level subjects tested positive for both antibody and CMI . In a comparison of the natural infection group (confirmed as IgG seropositive and/or CMI positive without vaccination) versus the vaccination group, IgG antibody titer (mean ± SD ) was 14.4 ± 8.0 versus 3.6 ± 2.4 index units ( P < 0.01) and IFN ‐γ was 122.7 ± 90.0 pg/mL versus 59.5 ± 37.8 pg/mL ( P > 0.05), respectively. Conclusion Vaccination or even natural mumps infection did not always induce both cellular and humoral immunity.