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Vitamin D receptor polymorphisms in immune thrombocytopenic purpura
Author(s) -
Yesil Sule,
Tanyildiz Hikmet Gulsah,
Tekgunduz Sibel Akpinar,
Toprak Sule,
Fettah Ali,
Dikmen Asiye Ugras,
Sahin Gurses
Publication year - 2017
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13273
Subject(s) - foki , calcitriol receptor , taqi , medicine , genotype , immune system , allele , immunology , vitamin d and neurology , thrombocytopenic purpura , allele frequency , polymorphism (computer science) , genetics , gene , biology
Background Vitamin D receptor ( VDR ) polymorphisms have been studied in immune‐mediated disorders, but not yet in immune thrombocytopenic purpura ( ITP ). We investigated whether VDR variants were associated with ITP in children. Methods The study included 44 children with a diagnosis of ITP and 100 healthy controls. Five VDR polymorphisms (Cdx‐2, FokI, BsmI, ApaI and TaqI) were genotyped and used to evaluate the association of VDR variants with ITP . Results The distribution of the three Cdx‐2 genotype groups ( GG , GA , and AA ) was significantly different between ITP patients and controls ( P = 0.025); the homozygous GG genotype of Cdx‐2 was overrepresented in ITP patients. The frequency of the A allele of Cdx‐2 was significantly different between patients and controls ( P = 0.01). The A allele of Cdx‐2 was associated with a decreased risk of ITP ( OR , 0.343; 95% CI : 0.150–0.782). No statistically significant difference was found between the ITP group and control group for Fok1, Bsm1, Apa1, and Taq1 polymorphisms ( P > 0.5). Conclusion There appears to be an interaction between the Cdx‐2 variant of VDR and childhood immune thrombocytopenia.