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Resolution of liver disease in transient abnormal myelopoiesis with fish oil emulsion
Author(s) -
Watanabe Toshihiko,
Amari Shoichiro,
Tsukamoto Keiko,
Ito Yushi,
Tomizawa Daisuke,
Yoshioka Takako,
Kanamori Yutaka
Publication year - 2017
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13250
Subject(s) - medicine , lipid emulsion , myelopoiesis , liver disease , fatty liver , disease , fish oil , pathology , fish <actinopterygii> , parenteral nutrition , microbiology and biotechnology , stem cell , fishery , biology , haematopoiesis
Abstract Neonates with Down syndrome are at risk of developing transient abnormal myelopoiesis ( TAM ), which is characterized by transient clonal myeloproliferation of the blast cells. TAM can resolve spontaneously, but some patients die at an early age due to organ failure. Liver fibrosis in TAM is a life‐threatening condition, but treatment options have not yet been established. Here, we report on the case of an infant with TAM complicated by liver disease, whose hyperbilirubinemia was successfully ameliorated with omega‐3 fatty acid (ω3 FA ) lipid emulsion. Timely ω3 FA lipid emulsion may be a feasible treatment for liver disease in TAM before serious liver damage develops.