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Reproducibility of corrected QT interval in pediatric genotyped long QT syndrome
Author(s) -
Ogawa Yoshiharu,
Tanaka Toshikatsu,
Kido Sachiko
Publication year - 2016
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13120
Subject(s) - medicine , reproducibility , qt interval , intraclass correlation , long qt syndrome , treadmill , cardiology , physical therapy , clinical psychology , statistics , mathematics , psychometrics
Reproducibility of corrected QT interval ( QT c), especially QT c after exercise, has not been thoroughly investigated. We reviewed charts of pediatric patients who underwent treadmill‐exercise stress testing without medication multiple times within 1 year. In patients with long‐ QT syndrome ( LQTS ; n = 22), the discrepancy in QT c between two treadmill exercise stress tests using Fridericia's formula was 14 ± 12 ms at rest, 13 ± 12 ms 4 min after exercise, with a maximum of 14 ± 12 ms after exercise. There was no statistically significant difference in QT c between the two tests. Intraclass correlation coefficients ( ICC ) were 0.84, 0.85, and 0.85, respectively. In controls (n = 13), the discrepancy in QT c was 18 ± 12 ms at rest, 14 ± 7 ms 4 min after exercise, with a maximum of 14 ± 9 ms after exercise. There was no significant difference in QT c between the two tests. ICC were 0.78, 0.80, and 0.80, respectively. QT c calculated using Bazett's formula also showed high reproducibility. Reproducibility of QT c in children is high at rest and after exercise.