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Crystalline nephropathy caused by tosufloxacin
Author(s) -
Matsubara Risa,
Kibe Tetsuya,
Nomura Takemasa
Publication year - 2016
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13116
Subject(s) - medicine , nephropathy , discontinuation , urinalysis , urology , urinary system , endocrinology , diabetes mellitus
A 14‐year‐old girl was treated for 3 days with tosufloxacin (450 mg twice a day) for acute bronchitis and then developed acute kidney injury. Renal ultrasound showed enlarged kidneys without hydronephrosis. Urinalysis indicated drug crystal casts (2–3/ HPF ), consistent with drug‐induced crystalline nephropathy. The patient recovered gradually with i.v. hydration and discontinuation of tosufloxacin, leading to the diagnosis of tosufloxacin crystalline nephropathy. Medical practitioners should be aware that crystalline nephropathy can occur in pediatric patients receiving tosufloxacin.