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Time course of cardiac lesions due to Kawasaki disease in Japan: 22nd nationwide survey (2011–2012)
Author(s) -
Goto Takahiro,
Sano Takashi,
Kojo Takao,
Ae Ryusuke,
Aoyama Yasuko,
Makino Nobuko,
Kotani Kazuhiko,
Nakamura Yosikazu
Publication year - 2016
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13059
Subject(s) - medicine , kawasaki disease , disease , pediatrics , cardiology , artery
Background Although Kawasaki disease ( KD ) cardiac lesions can be treated with i.v. immunoglobulin ( IVIG ) and are associated with age and sex, the time course of cardiac lesions remains unclear on the large scale. Methods We used the data of the 22nd nationwide survey of KD in Japan (2011–2012). We divided the time course of cardiac lesions into eight groups according to the combination of timing (first visit to hospital, acute phase, and sequelae) and presence of cardiac lesions (E, existence of cardiac lesions; N, non‐existence of cardiac lesions): EEE , EEN , ENE , NEE , ENN , NEN , NNE , and NNN . For example, EEN shows that cardiac lesions existed at first visit to hospital and in the acute phase, but did not exist as sequelae. A total of 24 952 patients were analyzed. Results The majority (90.6%) of patients belonged to the NNN group, followed by the EEN (3.21%) and NEN (3.33%) groups. Male sex and ages ≤5 months and ≥5 years tended to be more prevalent. Non‐response to initial IVIG therapy was the most prevalent in all groups other than NNN . Conclusions The time course of cardiac lesions and the relationship with sex, age, and IVIG therapy have been described. KD patients who are male, aged ≤5 months or ≥5 years, and non‐responders to initial IVIG tend to have cardiac lesions at some point in the time course of KD .