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Medulloblastoma with epithelioid features in the cerebellar vermis
Author(s) -
Miyata Kenji,
Hori Toshinori,
Yamakawa Kiyoshi,
Takasu Michihiko,
Hayakawa Tomohito,
Shimomura Yasuto,
Iwata Atsuko,
Okumura Akihisa,
Nakura Takahiro,
Jyoko Masahiro,
Mori Yoshimasa,
Takahashi Emiko,
Hirato Junko
Publication year - 2016
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12998
Subject(s) - medicine , medulloblastoma , cerebellar vermis , magnetic resonance imaging , lesion , pathology , radiology , cerebellum
Abstract A 6‐year‐old girl was admitted with a mass lesion in the cerebellar vermis. She underwent subtotal tumor resection, and on immunohistopathology the tumor consisted of two different parts: typical medulloblastoma (MB) characteristics and atypical teratoid/rhabdoid tumor (AT/RT) features, despite positive integrase interactor 1 expression. The patient was diagnosed with MB with epithelioid features. Chemoradiation therapy was started because of tumor recurrence at the primary site and dissemination to the spinal cord, as determined on magnetic resonance imaging 2 weeks after surgery. The patient died due to tumor progression 13 months after initial diagnosis, although transient partial remission was achieved.