Ampicillin‐ and ampicillin/sulbactam‐resistant   Escherichia coli   infection in a neonatal intensive care unit in Japan | Zendy

Saida Ken | Zendy; Ito Yukako | Zendy; Shima Yosuke | Zendy; Kasuga Eriko | Zendy; Kusakari Mai | Zendy; Miyosawa Yukihide | Zendy; Baba Atsushi | Zendy

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Ampicillin‐ and ampicillin/sulbactam‐resistant Escherichia coli infection in a neonatal intensive care unit in Japan

Author(s) -

Saida Ken,

Ito Yukako,

Shima Yosuke,

Kasuga Eriko,

Kusakari Mai,

Miyosawa Yukihide,

Baba Atsushi

Publication year - 2016

Publication title -

pediatrics international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.49

H-Index - 63

eISSN - 1442-200X

pISSN - 1328-8067

DOI - 10.1111/ped.12984

Subject(s) - medicine , ampicillin , neonatal intensive care unit , escherichia coli , sulbactam , intensive care unit , incidence (geometry) , microbiology and biotechnology , amp resistance , population , pediatrics , antibiotic resistance , antibiotics , biology , environmental health , biochemistry , physics , optics , imipenem , gene

The incidence of ampicillin (ABPC)‐resistant Escherichia coli ( E . coli ) infection in very low‐birthweight infants has been increasing. The rate of ABPC/sulbactam (ABPC/SBT)‐resistant E . coli in this population, however, is currently unknown. We encountered two cases of severe infection due to resistant E. coli and retrospectively studied the prevalence of ABPC‐ and ABPC/SBT‐resistant E . coli in regular surveillance cultures obtained from all neonatal intensive care unit (NICU) patients between 2000 and 2013. The overall prevalence of ABPC‐resistant E . coli was 39% (47/120), accounting for 63% of cases (32/51) between 2007 and 2013, compared with 22% (15/69) between 2000 and 2006. The prevalence of ABPC/SBT resistance was 17% (20/120), which was similar in both periods (16%, 8/51 vs 17%, 12/69). According to these results, not only ABPC, but also ABPC/SBT‐resistant E . coli must be considered in the NICU.

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