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Increased oxidative stress in patients with severe disability: Association with nutrition
Author(s) -
Kawaguchi Chiharu,
Morinaga Marie,
Kubota Masaru,
Saito Hiromi,
Tomiwa Kiyotaka,
Uchiike Nobuo
Publication year - 2016
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12977
Subject(s) - oxidative stress , medicine , micronutrient , antioxidant , antioxidant capacity , physiology , oxidative phosphorylation , nutrient , pathology , biochemistry , biology , ecology
Background Previous studies have described a role of oxidative stress in the pathogenesis of various pediatric disorders, but investigation into oxidative stress status in patients with severe disability remains limited. The aim of the present study was therefore to clarify the oxidative stress status in patients with severe disability, focusing specifically on intake of three major nutrients and micronutrients with antioxidant activities. Methods Thirty‐one patients with severe disability (mean age, 14.1 ± 7.8 years) were enrolled. Three in vivo biomarkers, plasma biological antioxidant potential (BAP), plasma reactive oxygen metabolite‐derived compounds (d‐ROM), and urinary 8‐hydroxydeoxyguanosine (8‐OHdG), were determined for evaluating oxidative status. The dietary intake of three major nutrients and various micronutrients was estimated from dietary records over a 3 day period. Results In patients with severe disability, BAP was significantly lower and d‐ROM and 8‐OHdG significantly higher than in historical controls. Among these markers, a significant positive correlation was found in BAP versus d‐ROM and d‐ROM versus 8‐OHdG. On multiple regression analysis, a significant inverse association between 8‐OHdG and carotenoid intake was seen. Conclusion The oxidative/antioxidative balance shifts towards oxidative status dominance in patients with severe disability. More research is needed on nutritional intake of antioxidative nutrients to determine whether they can be used to reduce oxidative stress.