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Ewing sarcoma/primitive neuroectodermal tumor of the kidney treated with chemotherapy including ifosfamide
Author(s) -
Yoshihara Hiroki,
Kamiya Takahiro,
Hosoya Yosuke,
Hasegawa Daisuke,
Ogawa Chitose,
Asanuma Hiroshi,
Mizuno Ryuichi,
Hosoya Ryota,
Manabe Atsushi
Publication year - 2016
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12963
Subject(s) - ifosfamide , medicine , etoposide , nephrectomy , primitive neuroectodermal tumor , chemotherapy , nephrotoxicity , sarcoma , ewing's sarcoma , kidney , urology , surgery , pathology
Abstract Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) of the kidney is extremely rare, and is usually diagnosed after nephrectomy without neoadjuvant chemotherapy. Although ifosfamide and etoposide improve survival to a great extent in ES/PNET, the use of nephrotoxic agent, particularly ifosfamide, is a concern after nephrectomy. We describe the case of a 14‐year‐old female patient with abdominal mass who was diagnosed with ES/PNET of the right kidney after nephrectomy. Adjuvant chemotherapy including ifosfamide and etoposide were given. The estimated glomerular filtration rate decreased to 75% after the end of therapy. There was no evidence of recurrence 70 months after initial diagnosis.