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Transient hyperphosphatasemia after pediatric liver transplantation
Author(s) -
Yoshimaru Koichiro,
Matsuura Toshiharu,
Hayashida Makoto,
Kinoshita Yoshiaki,
Takahashi Yoshiaki,
Yanagi Yusuke,
Esumi Genshiro,
Taguchi Tomoaki
Publication year - 2016
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12914
Subject(s) - medicine , liver transplantation , alkaline phosphatase , gastroenterology , incidence (geometry) , elevated alkaline phosphatase , transplantation , liver function , liver function tests , liver enzyme , surgery , enzyme , biochemistry , chemistry , physics , optics
Background Transient hyperphosphatasemia (TH), the incidence of which in healthy children is 1.5–2.8%, is associated with a temporary elevation of serum alkaline phosphatase (ALP) without any other liver function test (LFT) abnormalities. Fast α 2 band, detected on agarose gel electrophoresis, is known to be a highly sensitive phenomenon in TH. The aim of this study was to elucidate the characteristics of TH after liver transplantation (LT). Methods Five TH patients (6.0%) out of 83 who underwent LT between October 1996 and October 2014, were included in this study. Patient background, duration of TH, peak ALP, time course of ALP and its isoenzyme in TH, other LFT, and imaging results were retrospectively investigated. Results Median patient age at the time of peak ALP during TH was 24 months (range, 16–98 months). Mean duration of TH was 111.0 ± 48.0 days. At 6887 IU/L, median ALP was elevated without any other LFT abnormalities. The first α 2 band was detected in all patients, and the band disappeared at the same phase of ALP normalization. All of the patients improved without any treatment. The prevalence of TH was significantly higher in the patients after LT than in age‐matched healthy children ( P < 0.05). Conclusions The detection of fast α 2 band in the early phase allows for effective diagnosis of TH after LT, and 3–4 month follow up without treatment is feasible.