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Cord blood transplantation in a young child with pyruvate kinase deficiency
Author(s) -
Akiyoshi Kensuke,
Sekiguchi Kazuhito,
Okamoto Tomoko,
Suenobu Soichi,
Izumi Tatsuro
Publication year - 2016
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12889
Subject(s) - pyruvate kinase deficiency , medicine , pyruvate kinase , cord blood , exon , hemolytic anemia , sibling , hemoglobin , transplantation , red blood cell , gene , biochemistry , glycolysis , metabolism , psychology , developmental psychology , chemistry
Abstract Unrelated cord blood transplantation (CBT) was performed for the treatment of pyruvate kinase (PK) deficiency in a female pediatric patient at the age of 1 year 7 months, who had been in severe and frequent transfusion‐dependent hemolytic anemia, despite red blood cell (RBC) PK activity 5.52 IU/gHb. pyruvate kinase‐liver and RBC ( PK‐LR ) had a compound heterozygous mutation located on exon 8: c.1044G > T/c.1076G > A (K348N/R359H). Hemoglobin and RBC PK corrected to 13.5 g/dL and 9.00 IU/gHb, respectively, with gene correction at 6 months after CBT. CBT should be considered as an option for useful treatment in children with severe PK deficiency in the absence of HLA identical sibling with normal RBC PK activity.