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Issue Information
Publication year - 2016
Publication title -
pediatrics international
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12793
Subject(s) - medicine , von willebrand factor , thrombospondin , citation , platelet , metalloproteinase , library science , matrix metalloproteinase , computer science
(a) Normal hemostasis with normal level of ADAMTS‐13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13), which cleaves von Willebrand factor (vWF) into smaller less coagulopathic forms. (b) Thrombocytopenia‐associated multi‐organ failure (TAMOF) with endothelial injury causing platelet activation. Decreased ADAMTS‐13 activity leads to larger more coagulopathic forms of vWF. Together these pathologic changes lead to systemic microthrombi in children with TAMOF. Cover picture from: Thrombocytopenia‐associated multi‐organ failure caused by diabetic ketoacidosis, Alsaied T et al. See pages 232–234. Article link here .