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Recurrent Staphylococcus aureus abscess and fatal pneumococcal septicemia due to IRAK‐4 deficiency
Author(s) -
Shichijo Koichi,
Ogose Takeshi,
Kubota Mari,
Tomimoto Ayumi,
Kondo Rieko,
Taniguchi Takako,
Takahashi Akiyoshi,
Nakatsu Tadanori,
Urano Yoshio,
Watanabe Tsutomu
Publication year - 2015
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12722
Subject(s) - medicine , staphylococcus aureus , microbiology and biotechnology , abscess , surgery , bacteria , biology , genetics
We describe the case of an infant with recurrent episodes of staphylococcal skin abscess and subsequent lethal pneumococcal meningitis/septicemia due to interleukin‐1 receptor‐associated kinase 4 (IRAK‐4) deficiency. In this case, systemic signs of inflammatory response were poor and delayed. Among all other reported cases of IRAK‐4 deficiency, none involved severe viral or fungal disease, and the range of infecting bacteria was narrow.