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Hematological findings in children with brucellosis
Author(s) -
Aypak Adalet,
Aypak Cenk,
Bayram Yasemin
Publication year - 2015
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12688
Subject(s) - medicine , brucellosis , pediatrics , intensive care medicine , immunology
Background Brucellosis produces a variety of non‐specific hematological abnormalities. The aim of the present study was to evaluate the hematological findings in childhood brucellosis. Methods Medical records of children with brucellosis admitted to a tertiary hospital in a 1 year period, were analyzed retrospectively. Results Sixty‐nine patients (mean age, 14.5 ± 3.3 years) were diagnosed with brucellosis. The most common hematological finding was thrombocytopenia (n = 11, 15.9%). Thrombocytosis was detected in five patients (7.3%), leukopenia in four (5.8%), anemia in three (4.3%), and bicytopenia in three (4.3%). None of the patients had pancytopenia. Blood culture was positive for Brucella spp. in 41 patients (59.4%). Among those patients with positive blood culture, six (14.6%) had serum agglutination test titer ≤1/80. Platelet (PLT) count was significantly lower in the bacteremia‐positive group. The OR (95%CI) of bacteremia for PLT cut‐off 200 000/mm 3 was 0.148 (95%CI: 0.031–0.718) and relative risk was 1.718 (95%CI: 1.244–2.372; P = 0.010). Conclusions Brucellosis should be kept in mind in the differential diagnosis of isolated thrombocytopenia in pediatric patients from endemic areas.