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Plasma H 2 S predicts coronary artery lesions in children with Kawasaki disease
Author(s) -
Sun Yan,
Yuan Yue,
Yan Hui,
Wan Hong,
Li Xueying,
Chen Siyao,
Li Hongxia,
Tang Chaoshu,
Du Junbao,
Liu Guiying,
Jin Hongfang
Publication year - 2015
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12631
Subject(s) - medicine , kawasaki disease , biomarker , receiver operating characteristic , coronary artery disease , prospective cohort study , plasma levels , acute coronary syndrome , stage (stratigraphy) , artery , area under the curve , cardiology , gastroenterology , myocardial infarction , paleontology , biochemistry , chemistry , biology
Background The aim of this study was to determine whether plasma hydrogen sulfide (H 2 S) is a biomarker for predicting coronary artery lesions (CAL) in children with Kawasaki disease (KD). Methods A prospective study was conducted on 50 KD patients and 27 healthy children. Plasma H 2 S was analyzed at the acute stage. Plasma H 2 S was detected using the sensitive electrode method, and receiver operating characteristic curve (ROC) analysis was carried out. Results Plasma H 2 S in KD patients at the acute stage was significantly lower than that of controls. CAL patients had reduced plasma H 2 S at acute stage compared with the non‐CAL patients. A plasma H 2 S cut‐off of 31.2 µmol/L provided a sensitivity of 81% and a specificity of 62.5% for predicting coronary injuries in KD. Optimal specificity and sensitivity were obtained when using plasma H 2 S to predict CAL in KD children. Conclusion Plasma H 2 S level in the acute period is a potentially useful biomarker for predicting CAL in KD children.
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