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Interleukin‐8‐producing primary cardiac undifferentiated sarcoma in a child with sustained fever
Author(s) -
Yanagisawa Ryu,
Nakamura Tomohiko,
Ogiso Yoshifumi,
Hachiya Akira,
Fujihara Ikuko,
Morita Daisuke,
Sakashita Kazuo,
Kitamura Masatomo,
Matsui Hikoro,
Nishijima Fumie,
Hayashi Hidetaka,
Hidaka Eiko,
Sano Kenji,
Shiohara Masaaki,
Yasukochi Satoshi
Publication year - 2015
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12621
Subject(s) - medicine , immunohistochemistry , angiogenesis , sarcoma , chemotherapy , pathology
We report the case of a 12‐year‐old boy with primary undifferentiated sarcoma of the left atrium. He had sustained fever during the clinical course and multiple lung and brain metastases. Chemotherapy and irradiation were ineffective; he died 41 days after hospitalization. On retrospective analysis, interleukin‐8 ( IL ‐8) was elevated; this was supported by immunohistochemistry and gene expression analysis of tumor samples. IL ‐8 continued to increase with tumor progression accompanied by elevated neutrophil count and C ‐reactive protein. IL ‐8 is involved in malignant tumor proliferation, migration, and angiogenesis and may have been related to the clinical condition and prognosis in the present case.