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Hemophagocytic lymphohistiocytosis following dengue hemorrhagic fever in H b H / H b Constant Spring patient
Author(s) -
Phuakpet Kamon,
Sanpakit Kleebsabai,
Vathassawee,
Takpradit Chayamon,
Chokephaibulkit Kulkanya,
Viprakasit Vip
Publication year - 2015
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12617
Subject(s) - medicine , hemophagocytic lymphohistiocytosis , dengue fever , immunology , thalassemia , disease
Infection‐associated hemophagocytic syndrome ( IAHS ), a secondary form of hemophagocytic lymphohistiocytosis ( HLH ), has been found following several types of infections and can be fatal. We report herein a case of IAHS following dengue infection in a 14‐year‐old patient with underlying α‐thalassemia syndrome (non‐deletional H b H / H b Constant Spring disease). He developed prolonged fever, thrombocytopenia, and progressive splenomegaly. Further investigations indicated hyperferritinemia, and increased reactive histiocytes with hemophagocytic activity in the bone marrow. He responded promptly to dexamethasone and i.v. immune globulin. Physicians should be aware of this condition, especially in countries where both dengue hemorrhagic fever and thalassemia are prevalent. The fatal outcome of IAHS can be prevented with prompt appropriate treatment.