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Diffuse alveolar hemorrhage secondary to ANCA ‐associated vasculitis in a patient with Down syndrome
Author(s) -
Hori Ikumi,
Nakaseko Haruna,
Kamei Michi,
Nomura Takayasu,
Iwata Naomi,
Ito Yasuhiko,
Saitoh Shinji
Publication year - 2015
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12612
Subject(s) - medicine , diffuse alveolar hemorrhage , vasculitis , pulmonary hemorrhage , pathology , pathogenesis , immunology , lung , disease
Diffuse alveolar hemorrhage ( DAH ) is a rare disease characterized by dyspnea, cough, hemoptysis, and new alveolar infiltrates. Among the various underlying disorders, vasculitis is believed to play a significant role in the pathogenesis of DAH . Here we report the first case of a patient with D own syndrome who developed DAH secondary to anti‐neutrophil cytoplasmic antibody‐associated vasculitis. This case highlights the significance of vasculitis as well as pulmonary hypoplasia and vulnerability associated with D own syndrome in the development of DAH .