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Severe intrinsic acute kidney injury associated with therapeutic doses of acetaminophen
Author(s) -
Ito Tatsuya,
Watanabe Shojiro,
Tsuruga Kazushi,
Aizawa Tomomi,
Hirono Koji,
Ito Etsuro,
Joh Kensuke,
Tanaka Hiroshi
Publication year - 2015
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12607
Subject(s) - medicine , acetaminophen , acute kidney injury , acute tubular necrosis , dose , therapeutic effect , renal biopsy , kidney , kidney disease , anesthesia
Acetaminophen is a commonly used medication to manage fever and pain in children and the drug is generally considered to be safe when used at appropriate therapeutic dosages. Recently, we encountered the case of a 3‐year‐old Japanese girl who suffered from severe intrinsic acute kidney injury ( AKI ) after therapeutic doses of acetaminophen for a fever due to viral infection. Renal biopsy indicated severe acute tubular necrosis with a significant striped interstitial fibrosis and mild interstitial inflammation. Unfortunately, she developed chronic kidney disease thereafter. This is the youngest case of biopsy‐proven severe intrinsic AKI associated with therapeutic doses of acetaminophen. Acetaminophen, even if administered at therapeutic dosages, may be dangerous in selected children, especially with possible pre‐existing volume depletion.