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Pulmonary arterial hypertension associated with chronic active Epstein–Barr virus infection
Author(s) -
Fukuda Yutaka,
Momoi Nobuo,
Akaihata Mitsuko,
Nagasawa Katsutoshi,
Mitomo Masaki,
Aoyagi Yoshimichi,
Endoh Kisei,
Hosoya Mitsuaki
Publication year - 2015
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12578
Subject(s) - medicine , hepatosplenomegaly , mononucleosis , cardiology , myocarditis , virus , immunology , disease
Abstract Chronic active Epstein–Barr virus ( EBV ) infection ( CAEBV ), characterized by persistent infectious mononucleosis‐like symptoms, can lead to cardiovascular complications including coronary artery aneurysm or myocarditis. Here, we present the case of an 11‐year‐old boy with pulmonary arterial hypertension ( PAH ) and junctional ectopic tachycardia associated with CAEBV . The patient did not have any major symptoms attributed to CAEBV , such as fever, lymphadenopathy or splenomegaly when the PAH developed. Mild liver dysfunction was found at the first examination, and it persisted. Two years after the PAH symptoms appeared, CAEBV was evident, based on deteriorated liver function, hepatosplenomegaly, and coronary artery aneurysms. CAEBV should be considered as a cause of secondary PAH , particularly when liver dysfunction coexists.