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Rotavirus‐associated hemophagocytic lymphohistiocytosis ( HLH ) after hematopoietic stem cell transplantation for familial HLH
Author(s) -
Park Meerim,
Yun Yeong Ju,
Woo Sung Il,
Lee Jae Wook,
Chung NackGyun,
Cho Bin
Publication year - 2015
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12567
Subject(s) - hemophagocytic lymphohistiocytosis , medicine , fulminant , hematopoietic stem cell transplantation , immunology , immune dysregulation , septic shock , sepsis , coagulopathy , immune system , transplantation , disease
Abstract Hemophagocytic lymphohistiocytosis ( HLH ) is a life‐threatening disorder of immune regulation. HLH consists of two forms: familial and acquired, the latter which occurs in association with infection, malignancy, rheumatic disease and acquired immune deficiency. Herein, we report a case of acquired HLH in a child who had received allogeneic hematopoietic stem cell transplantation for familial HLH with UNC13D mutation. Based on microbiology, only rotavirus was identified as a possible organism triggering HLH . The patient's fulminant clinical course included acute respiratory failure, a sepsis‐like pattern, disseminated intravascular coagulopathy, and rhabdomyolysis, leading to multiorgan failure and death from septic shock.