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Total antioxidant and total oxidant states, and serum paraoxonase‐1 in neonatal sepsis
Author(s) -
Annagür Ali,
Örs Rahmi,
Altunhan Hüseyin,
Kurban Sevil,
Ertuğrul Sabahattin,
Konak Murat,
Uygun Saime Sündüz,
Pekcan Sevgi,
Erbay Ekrem,
Mehmetoğlu İdris
Publication year - 2015
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12557
Subject(s) - medicine , sepsis , paraoxonase , neonatal sepsis , arylesterase , oxidative stress , antioxidant , gastroenterology , biomarker , endocrinology , immunology , pon1 , biochemistry , genotype , chemistry , gene
Background Paraoxonase‐1 ( PON ‐1) is an enzyme with a glycoprotein structure that depends on calcium and which is located in serum high‐density lipoprotein ( HDL ). The aim of this study was to evaluate PON ‐1, and oxidant/antioxidant state, before and after treatment for neonatal sepsis, and to determine the usability of PON ‐1 in neonatal sepsis treatment. Methods A total of 35 neonatal sepsis patients and 35 healthy controls were included in the study. Activity of PON ‐1, total oxidant state ( TOS ) and total antioxidant state ( TAS ) were measured and oxidative stress index ( OSI ) was calculated. Results In the neonatal sepsis patients, pre‐treatment TAS , TOS and OSI were significantly higher than the post‐treatment levels ( P < 0.0001, P < 0.0001 and P < 0.0001, respectively), and PON ‐1 was significantly lower ( P < 0.0001). Similarly, pre‐treatment TAS , TOS and OSI in the sepsis group were also significantly higher than in the control group ( P < 0.0001, P < 0.0001 and P < 0.0001, respectively) and PON ‐1 was significantly lower ( P < 0.0001). Post‐treatment TAS in the sepsis group was significantly higher than in the control group ( P = 0.009), whereas post‐treatment TOS , OSI and PON ‐1 in the sepsis group were not significantly different to the control group ( P = 0.078, P = 0.597 and P = 0.086, respectively). Conclusion Low serum PON ‐1 was found in neonatal sepsis. Serum PON ‐1 is thought to be a useful biomarker to evaluate the effectiveness of treatment and recovery in neonatal sepsis.