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Gut hormones of preterm infants with abdominal symptoms and hypothyroxinemia
Author(s) -
Kawamata Ryou,
Suzuki Yume,
Yada Yukari,
Koike Yasunori,
Kono Yumi,
Takahashi Naoto
Publication year - 2015
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12556
Subject(s) - medicine , peptide yy , hormone , endocrinology , amylin , leptin , glucagon , ghrelin , pancreatic polypeptide , gestational age , thyroid function , insulin , pregnancy , obesity , islet , neuropeptide , receptor , neuropeptide y receptor , biology , genetics
Background The pathogenesis of abdominal symptoms in premature infants with hypothyroxinemia is not understood; therefore, we investigated changes in gut hormones before and after levothyroxine sodium ( T4 ‐ N a) supplementation in preterm infants with abdominal symptoms and hypothyroxinemia. Methods In eight preterm study subjects and 14 gestational age‐matched controls, fasting serum concentration of leptin, glucose‐dependent insulinotropic polypeptide ( GIP ), glucagon‐like peptide‐1 ( GLP ‐1), peptide YY ( PYY ), pancreatic polypeptide, insulin, amylin and ghrelin was measured using a bead array system. Results Serum GLP ‐1, GIP and PYY in the subjects before T4 ‐ N a supplementation were lower than in controls at age 2 weeks. After improvement of abdominal symptoms and free thyroxine, serum levels of the three gut hormones in the subjects were increased and were not different from those in the control patients. Conclusions In preterm infants with abdominal symptoms, serum GLP ‐1, GIP and PYY might be related to thyroid function.