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Intestinal neuronal dysplasia‐like histopathology in infancy
Author(s) -
Hirayama Yutaka,
Iinuma Yasushi,
Numano Fujito,
Masui Daisuke,
Iida Hisataka,
Komatsuzaki Naoko,
Nagayama Yosihisa,
Naito Shinichi,
Nitta Koju
Publication year - 2015
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12555
Subject(s) - medicine , pathological , histopathology , exploratory laparotomy , biopsy , pathology , gastroenterology , surgery
The present patient was delivered at a gestational age of 27 weeks. She had abdominal bloating with symptoms of respiratory distress. We suspected Hirschsprung disease ( HD ) or small intestinal stricture, but examinations were not definitive. Exploratory laparotomy was performed at 97 days of age. Intraoperative findings showed no evidence of small intestinal stricture or changes in intestinal caliber. A transanal drainage tube was inserted, and decompression therapy and intestinal lavage were started. Rectal mucosal biopsy was performed at 184 days of age, and HE and acetylcholinesterase staining showed intestinal neuronal dysplasia ( IND )‐like pathological findings. At 15 months, giant ganglia were no longer present on follow‐up rectal mucosal biopsy, and the pathological diagnosis was normoganglionosis. It should be recognized that while the enteric nervous system is developing, IND ‐like pathological findings may be seen as a pathological condition during the maturation process.