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Serum ischemia‐modified albumin and oxidized LDL in cord blood and serum of neonates born to pre‐eclamptic mothers
Author(s) -
Mehmetoglu Idris,
Kurban Sevil,
Toker Aysun,
Annagür Ali,
Altunhan Hüseyin,
Erbay Ekrem,
Örs Rahmi
Publication year - 2015
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12552
Subject(s) - medicine , cord blood , venous blood , ischemia modified albumin , albumin , eclampsia , cord , oxidative stress , umbilical cord , ischemia , endocrinology , pregnancy , immunology , surgery , myocardial ischemia , biology , genetics
Background We investigated oxidized low‐density lipoprotein ( OxLDL ) and ischemia‐modified albumin ( IMA ) in cord blood and neonatal blood of 7‐day‐old neonates born to pre‐eclamptic and normotensive healthy mothers. Methods The study was performed on 30 neonates born to pre‐eclamptic and 20 neonates born to normotensive mothers. IMA and OxLDL were determined on spectrophotometry and ELISA, respectively. Results IMA in cord blood was higher in the pre‐eclamptic group as compared with the normotensive group, but the difference between the groups was not significant. IMA in neonate venous blood was significantly higher in the pre‐eclamptic group than in the normotensive group ( P < 0.001). OxLDL in both cord blood and in neonate venous blood was significantly higher in the pre‐eclamptic group compared with the normotensive group ( P < 0.001). IMA and OxLDL were significantly decreased after delivery in both groups. Conclusions Significantly increased cord blood OxLDL and significantly increased OxLDL and IMA 7 days after birth in neonates born to pre‐eclamptic mothers might be an indicator of increased oxidative stress in pre‐eclampsia.