Premium
KL ‐6 as a biomarker of respiratory complications in severely disabled children
Author(s) -
Ochi Fumihiro,
Fukuda Mitsumasa,
Ohmori Hiromitsu,
Yano Yoshiaki,
Wakamoto Hiroyuki,
Suzuki Yuka,
Ishii Eiichi
Publication year - 2015
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12537
Subject(s) - medicine , biomarker , occult , white blood cell , respiratory system , pneumonia , imaging biomarker , gastroenterology , pica (typography) , pediatrics , pathology , radiology , magnetic resonance imaging , biochemistry , chemistry , alternative medicine , world wide web , computer science
Abstract Background The aim of this study was to assess the importance of KL ‐6 level in evaluating the status of stabilized chronic pneumonia in children in the severe motor and intellectual disabilities–medical care‐dependent ( SMID‐MCD ) category. Methods A total of 20 SMID‐MCD children were enrolled in this study. Serum KL ‐6, white blood cell count, C ‐reactive protein, chest computed tomography ( CT ) and other factors related to respiratory complications were analyzed in all children under stable respiratory conditions. Results Mean age was 5.8 ± 1.0 years (mean ± SE ). Serum KL ‐6 was significantly higher in those SMID‐MCD children with abnormal CT than in those with normal CT: 316 ± 39 U/mL versus 190 ± 11, respectively ( P = 0.0075). Conclusions Measures of serum KL ‐6 level provide valuable information for determining the respiratory management of SMID‐MCD children with occult chronic pneumonia.