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Rotavirus gastroenteritis‐associated urinary ammonium acid urate crystals
Author(s) -
Yokoyama Tadafumi,
Sugimoto Naotoshi,
Kato Eiji,
Ohta Kazuhide,
Ishikawa Sayaka,
Ueno Kazuyuki,
Shimizu Masaki,
Yachie Akihiro
Publication year - 2015
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12405
Subject(s) - medicine , uric acid , rotavirus , urinary system , urine , excretion , rotavirus gastroenteritis , gastroenterology , ammonium , acute gastroenteritis , diarrhea , virology , chemistry , organic chemistry
Although ammonium acid urate ( AAU ) calculi are extremely rare renal stone components, it was recently found that many urinary tract calculi that cause post‐renal renal failure in rotavirus ( RV ) gastroenteritis are AAU calculi. The mechanism of AAU calculi development in RV gastroenteritis has not been fully elucidated. We analyzed data from eight RV gastroenteritis patients who transiently had AAU crystals in their urinary sediment. In these patients, formation of AAU crystals occurred earlier than the formation of AAU calculi. No difference was observed in serum and urine uric acid levels between RV gastroenteritis patients with or without AAU crystals. Interestingly, fractional excretion of sodium was extremely low among patients with AAU crystals. These results suggest that the formation of AAU crystals might not be due to excretion of uric acid, but excretion of sodium.