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Correlation between hyperglycemia and retinopathy of prematurity
Author(s) -
AhmadpourKacho Mousa,
Jashni Motlagh Alireza,
Rasoulinejad Seyed Ahmad,
Jahangir Tahereh,
Bijani Ali,
Zahed Pasha Yadollah
Publication year - 2014
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12371
Subject(s) - medicine , retinopathy of prematurity , gestational age , neonatal intensive care unit , incidence (geometry) , logistic regression , birth weight , pediatrics , retrospective cohort study , pregnancy , genetics , physics , optics , biology
Background Several risk factors are attributed to retinopathy of prematurity ( ROP ). This study was done to determine any association between hyperglycemia and ROP in premature infants. Methods In a retrospective case–control analysis, all infants with a gestational age ( GA ) < 34 weeks and a birthweight ( BW ) < 2000 g admitted and treated in the N eonatal I ntensive C are U nit at A mirkola C hildren's H ospital, I ran, during M arch 2007– S eptember 2010 were included. Hyperglycemia was defined as a plasma glucose level of >150 mg/dL during the hospital stay. The duration of being hyperglycemic was also recorded. All of these neonates were examined for ROP by a retinologist unaware of group assignment. The difference in the ROP incidence and also the severity of ROP was compared between the hyperglycemic and non‐hyperglycemic infants. Matching was done for GA , BW , and also C linical R isk I ndex for B abies score. The data were analyzed by t ‐test, χ 2 ‐test and logistic regression test and a P < 0.05 was considered significant. Results In total, 155 neonates were examined. Seventy (45.2%) of them developed ROP but 85 (54.8%) did not show any evidence of ROP . The frequency of hyperglycemia in patients with ROP was 33 (47.2%), but in those without ROP , hyperglycemia occurred in five (5.9%) ( P = 0.0001). The severity of ROP showed no significant differences between the two groups ( P = 0.35). The logistic regression for GA and BW showed a significant correlation between hyperglycemia and ROP ( P = 0.0001). Conclusions Hyperglycemia is an important risk factor for ROP that can be prevented along with other risk factors by accurate supervision.