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Coexistence of neuroblastoma detected on staging of Langerhans cell histiocytosis
Author(s) -
Shiohama Tadashi,
Ochiai Hidemasa,
Hishiki Tomoro,
Yoshida Hideo,
Kohno Yoichi
Publication year - 2014
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12292
Subject(s) - medicine , langerhans cell histiocytosis , neuroblastoma , cervical lymphadenopathy , histiocytosis , biopsy , pathology , pathological , chemotherapy , disease , biology , genetics , cell culture
Langerhans cell histiocytosis ( LCH ) is a rare proliferative disease accompanied by the accumulation of pathological Langerhans cells, which often spreads into multi‐site and multi‐organ systems. We here describe a girl with a history of K awasaki disease and cervical lymphadenopathy who presented with occipital LCH . Adrenal tumor was detected on staging evaluation of LCH and was diagnosed as neuroblastoma on resection using laparoscopic surgery. Neither tumor relapsed following chemotherapy for LCH and resection of neuroblastoma. Although LCH often spreads into multi‐organ lesions, invasive biopsy may be needed for tumors with atypical localization for LCH in consideration of the synchronous occurrence of malignancies.