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Neonatal leukemoid reaction associated with C andida albicans chorioamnionitis
Author(s) -
Iwatani Sota,
Mizobuchi Masami,
Sofue Toshiki,
Tanaka Satoshi,
Sakai Hitomi,
Yoshimoto Seiji,
Nakao Hideto
Publication year - 2014
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12259
Subject(s) - chorioamnionitis , medicine , leukocytosis , candida albicans , leukemoid reaction , placenta , umbilical cord , corpus albicans , endometritis , pregnancy , obstetrics , gestation , microbiology and biotechnology , immunology , fetus , biology , genetics
Abstract Chorioamnionitis due to C andida species is relatively rare, despite the high prevalence (20–25%) of C andida vulvovaginitis during pregnancy. We describe a case of neonatal leukemoid reaction ( NLR ) associated with C andida albicans chorioamnionitis. A male infant was born at 31 weeks' gestation and weighed 1864 g. Laboratory tests at birth indicated marked leukocytosis (i.e. total leukocyte count 89.8 × 10 9 /L including 66% polymorphonuclear leukocytes and 15% band forms). Samples of the infant's pharyngeal mucus and tracheal aspirate were positive for C andida albicans . On further histopathology of the placenta, C . albicans mycelia had invaded the placenta, chorioamniotic membrane, and umbilical cord. Although it is not very common, C . albicans chorioamnionitis should be considered in preterm infants with NLR .