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Fat emulsion given to very low‐birthweight infants increases urinary l ‐ FABP
Author(s) -
Suganuma Hiroki,
Ikeda Naho,
Ohkawa Natuki,
Nagata Satoru,
Shoji Hiromichi,
Shimizu Toshiaki
Publication year - 2014
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12223
Subject(s) - medicine , urinary system
Background In premature infants, many factors influence the function of renal tubules, such as asphyxia, respiratory disorders, use of high‐concentration oxygen, hypotension, and drug treatment. When tubular ischemia and oxidative stress develop due to renal microcirculatory pathology, urinary l ‐type fatty acid‐binding protein ( l ‐ FABP ) level increases. Methods Urinary l ‐ FABP level was measured over time in very low‐birthweight infants ( VLBWI ), and the effect of fat emulsion on l ‐ FABP level was investigated. Thirty‐one VLBWI were divided into two groups with regard to treatment with fat emulsion: the lipid group ( n = 20) and the control group ( n = 11). Urinary l ‐ FABP was measured before (0–3 days of age), during (7–14 days of age), and after fat emulsion treatment (21–28 days of age) in the two groups. Results Median urinary l ‐ FABP level before treatment was 459 ng/mgCr (range, 22.7–5100 ng/mgCr; mean, 1067 ± 1570 ng/mgCr) and 797 ng/mgCr (range, 69–3900 ng/mgCr; mean, 1066 ± 1188 ng/mgCr) in the lipid and control groups, respectively, showing no significant difference. Median urinary l ‐ FABP level was 624 ng/mgCr (range, 50–2050 ng/mgCr; mean ± SD, 799 ± 655 ng/mgCr) and 273 ng/mgCr (range, 31–987 ng/mgCr; mean ± SD, 359 ± 323 ng/mgCr) at 7–14 days of age, respectively, showing that the level was significantly higher in the lipid group. At 21–28 days of age, the median level was 462 ng/mgCr (range, 49–1867 ng/mgCr; mean ± SD, 557 ± 534 ng/mgCr) and 130 ng/mgCr (range, 20–993 ng/mgCr; mean ± SD, 290 ± 329 ng/mgCr), respectively, showing that l ‐ FABP level tended to be higher in the lipid group. Conclusions Fat emulsion treatment induced a significant increase in urinary l ‐ FABP level, suggesting that fat emulsion affected the proximal tubule in VLBWI .