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Arterial function and anatomy in obese children with cardiovascular risk factors
Author(s) -
Guven Baris,
Demirpence Savas,
Yilmazer Murat Muhtar,
Carti Ozgur Umac,
Tavli Vedide,
Mese Timur,
Oner Taliha
Publication year - 2013
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12177
Subject(s) - medicine , arterial stiffness , cardiology , hyperinsulinemia , brachial artery , blood pressure , insulin resistance , pulse wave velocity , body mass index , insulin
Background Limited data are available related to the effects of cardiovascular risk factors on abdominal arterial stiffness using carotid and brachial artery indices. Therefore, we aimed to determine arterial changes in obese children and investigate any relation with cardiovascular risk factors. Methods Thirty‐eight obese children (mean body mass index: 28.35 ± 4.65 kg/m 2 ) and 34 age‐ and sex‐matched healthy subjects underwent ultrasound measurements of abdominal, carotid and brachial arteries. Aortic strain, pressure strain elastic modulus ( Ep ), pressure strain normalized by diastolic blood pressure ( Ep *), carotid intima‐media thickness, carotid artery compliance, brachial artery flow‐mediated dilatation, and well‐known cardiovascular risk factors were assessed in the obese children. Results Obese children had significantly higher Ep and Ep * parameters than the healthy controls (mean: 242.6 [107.1–666.6], 164.2 [110.6–231.5]; P < 0.001, and mean: 3.39 [1.76–7.5], 2.64 [1.46–4.2]; P < 0.001, respectively). Ep and Ep * were significantly correlated with the homeostasis model assessment of insulin resistance (r = 0.587, P = 0.001; r = 0.467, P = 0.004, respectively). Receiver–operator curve analysis of Ep for identification of children with cardiovascular risk factors showed that the area under the curve for hyperinsulinemia was 0.80 ( P < 0.001) and for hypertriglyceridemia was 0.62 ( P < 0.01). Conclusions Abdominal arterial stiffness parameters as well as carotid intima‐media thickness and brachial arterial flow‐mediated dilatation assessment were similarly useful in identifying obese children with cardiovascular risk factors. Insulin resistance is related with the augmented rigidity of the aortic wall in obese children.