Premium
Decreased sialylation of IgA1 O ‐glycans associated with pneumococcal hemolytic uremic syndrome
Author(s) -
Aoki Hisaaki,
Shiomi Masashi,
Ikeda Tae,
Ishii Tsubura,
Shimizu Nobuhiko,
Togawa Masao,
Okamoto Nobuhiko,
Kadoya Machiko,
Wada Yoshinao
Publication year - 2013
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12166
Subject(s) - medicine , glycan , microbiology and biotechnology , pneumococcal pneumonia , transferrin , immunology , antigen , sialic acid , pneumonia , streptococcus pneumoniae , glycoprotein , biochemistry , biology , antibiotics
Hemolytic uremic syndrome ( HUS ) in children is usually caused by S higa‐like toxin‐producing E scherichia coli , but approximately 5% of cases are caused by invasive pneumococcal infection ( P ‐ HUS ). Reported herein is the case of a 9‐month‐old HUS patient with pneumococcal meningitis who needed hemodialysis for 12 days. Decreased sialylation was characterized in both transferrin N ‐glycans and IgA1 O ‐glycans, analyzed in the acute phase on mass spectrometry, consistent with S . pneumonia ‐produced sialidases hydrolyzing both α2,3‐ and α2,6‐linked sialic acids. The method will complement the T ‐antigen activation test and help to understand the molecular pathology related to P ‐ HUS .
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom