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Efficacy of recombinant human soluble thrombomodulin for childhood hemolytic uremic syndrome
Author(s) -
Kawasaki Yukihiko,
Suyama Kazuhide,
Ono Atsushi,
Oikawa Tomoko,
Ohara Shinichiro,
Suzuki Yuichi,
Sakai Nobuko,
Hosoya Mitsuaki
Publication year - 2013
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12165
Subject(s) - medicine , fibrinogen , disseminated intravascular coagulation , thrombomodulin , dialysis , gastroenterology , lactate dehydrogenase , fibrin , creatinine , albumin , immunology , thrombin , platelet , enzyme , biochemistry , chemistry
Recombinant human soluble thrombomodulin ( rhTM ) is a promising therapeutic natural anticoagulant and is used clinically for the treatment of disseminated intravascular coagulation ( DIC ). Herein is reported the cases of two HUS children treated with rhTM . The patients were diagnosed as having typical HUS on the basis of thrombocytopenia, hemolytic anemia, acute renal failure, and the detection E scherichia coli 0157. I.v. rhTM was started as an anti‐coagulant drug. At 2 days after the first treatment in both patients, fibrin/fibrinogen degradation products and d ‐dimer levels were significantly decreased, and there was a subsequent slight improvement in thrombocytopenia, and a decrease in serum lactate dehydrogenase level. Urinary protein excretion gradually diminished and a decrease in serum creatinine level was observed. The patients did not require dialysis therapy. The present results suggest that rhTM may be a safe and effective treatment for DIC complicated with HUS in children.