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Hour‐specific nomogram for transcutaneous bilirubin in J apanese neonates
Author(s) -
Kuboi Toru,
Kusaka Takashi,
Kawada Koh,
Koyano Kousuke,
Nakamura Shinji,
Okubo Kensuke,
Yasuda Saneyuki,
Isobe Kenichi,
Itoh Susumu
Publication year - 2013
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12149
Subject(s) - nomogram , medicine , percentile , jaundice , gestational age , bilirubin , pediatrics , area under the curve , pregnancy , statistics , mathematics , biology , genetics
Background The measurement of transcutaneous bilirubin ( TcB ) is very important to screen for hyperbilirubinemia in newborns. Until now, however, there has been no hour‐specific, percentile‐based TcB nomogram during the early neonatal period in Japanese neonates. The aim of this study was to develop a TcB nomogram within 72 h of birth in Japanese neonates. Methods A total of 3152 TcB measurements for 181 healthy Japanese neonates (gestational age ≥36 weeks, birthweight ≥2300 g) were obtained within 72 h of birth. All measurements were performed with a K onica M inolta jaundice meter, the JM ‐103. A nomogram curve was plotted to show the trend of TcB level over time. Results The nomogram curves rose almost linearly for all percentiles until 72 h after birth. Conclusion An hour‐specific, percentile‐based TcB nomogram during the first 72 h after birth in J apanese neonates was successfully developed. Because J apanese neonates have higher and later peak bilirubin, an original hour‐specific 97.5th percentile‐based TcB nomogram may be needed to identify early‐onset jaundice and manage neonatal hyperbilirubinemia.