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Case of cytomegalovirus‐associated direct anti‐globulin test‐negative autoimmune hemolytic anemia
Author(s) -
Kaneko Saeko,
Sato Masanori,
Sasaki Goro,
Eguchi Hiroyuki,
Oishi Tsutomu,
Kamesaki Toyomi,
Kawaguchi Hiroyuki
Publication year - 2013
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12128
Subject(s) - medicine , autoimmune hemolytic anemia , immunology , cytomegalovirus , globulin , antibody , virus , viral disease , herpesviridae
A 1‐year‐old boy developed autoimmune hemolytic anemia after a negative direct anti‐globulin test. The concentration of erythrocyte membrane‐associated immunoglobulin G, determined using an immunoradiometric assay, correlated with disease activity. He was positive for cytomegalovirus ( CMV ) both serologically and by quantitative real‐time polymerase chain reaction, indicating that his autoimmune hemolytic anemia was directly caused by CMV infection. Since anti‐ CMV immunoglobulin G was not absorbed by the patient's erythrocytes, cross‐reaction between erythrocyte antigens and CMV was not likely a causative factor for hemolysis.