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Paroxysmal cold hemoglobinuria caused by an IgM ‐class D onath– L andsteiner antibody
Author(s) -
Hayashi Hisako,
Yasutomi Motoko,
Hayashi Taihei,
Yuasa Miori,
Kawakita Akiko,
Hata Ikue,
Tanizawa Akihiko,
Muramatsu Hideki,
Kojima Seiji,
Ohshima Yusei
Publication year - 2013
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12110
Subject(s) - medicine , antibody , immunology
We report on a 4‐year‐old boy who developed paroxysmal cold hemoglobinuria ( PCH ) following the first dose of a seven‐valent pneumococcal conjugate vaccine. He was admitted because of dark urine after exposure to cold air. Laboratory tests indicated anemia, increased serum indirect bilirubin and lactate dehydrogenase, and decreased serum haptoglobin. D onath– L andsteiner ( D‐L ) test was positive. The D‐L antibody belonged to the IgM class and exhibited anti‐ P specificity. Symptoms and signs subsided after supportive care without any medication. Although PCH is often associated with viral or bacterial infection and is caused by IgG ‐class D‐L antibodies with anti‐ P specificity, this case was unique because a D‐L antibody of the IgM class with anti‐ P specificity caused PCH after immunization with a pneumococcal vaccine.