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Neonatal lupus erythematosus complicated by improved congenital complete heart block
Author(s) -
Isayama Tetsuya,
Inamura Noboru,
Shiono Nobuko,
Kitajima Hiroyuki
Publication year - 2013
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12073
Subject(s) - medicine , heart block , gestation , antibody , cardiology , systemic lupus erythematosus , atrioventricular block , cardiomyopathy , fetus , heart rate , lupus erythematosus , immune system , pregnancy , immunology , heart failure , electrocardiography , blood pressure , disease , biology , genetics
Abstract Complete congenital heart block ( CCHB ) accompanied with neonatal lupus erythematosus is caused by an immune reaction between maternal anti‐ R o/ SSA antibodies and the fetal heart and is generally considered an irreversible process. This reaction mostly occurs before 30 weeks' gestation, especially between the 20th and 24th week. Reported here is an atypical case of neonatal lupus erythematosus with CCHB detected after 32 weeks' gestation that showed postnatal improvement in the degree of heart block after preterm delivery and immunoglobulin use. The clinical condition of the infant worsened with an increase in heart rate due to possible cardiomyopathy induced by the immune reaction.