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Effect of early measles vaccination ( AIK ‐ C strain) for preterm infants
Author(s) -
Ichikawa Tomonori,
Tsuji Atsutoshi,
Fujino Motoko,
Kusano Ryousuke,
Sugiyama Ryusuke,
Oomori Sayu,
Mori Kazuhiro,
Maeyama Katsuhiro,
Nakayama Tetsuo
Publication year - 2013
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12064
Subject(s) - medicine , measles , vaccination , gestational age , titer , immunization , measles vaccine , antibody , serology , antibody titer , outbreak , pediatrics , immunology , virology , pregnancy , genetics , biology
Background The level of maternal antibodies decreases more quickly in preterm than term infants, leaving them unprotected against measles. To protect premature infants from measles, an early vaccination trial was investigated. Methods Changes in the serum measles neutralization test ( NT ) antibody titer were examined in 152 infants (average gestational period, 29 weeks; average birthweight, 1203 g). Results The average antibody titer (2 n ) was 2 3.5 at birth and 2 2.2 at 1–3 months of age, and in all cases, NT antibody titer decreased to <1:4 (150 IU /mL). The AIK ‐ C measles vaccine was given to 17 preterm infants at the age of 6 months, and induced sufficient serological responses without any serious adverse events. NT antibody level did not decay during 12 months after vaccination. Conclusion Early immunization at 6 months of age is effective to protect preterm infants in the outbreak setting.
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