Premium
E scherichia coli brain abscess in a twin pair associated with TLR 4 gene mutation
Author(s) -
Erdemir Aydin,
Kahramaner Zelal,
Cosar Hese,
Turkoglu Ebru,
Sutcuoglu Sumer,
Uygun Dilara Kocacik,
Yegin Olcay,
Berdeli Afig,
Ozer Esra Arun
Publication year - 2013
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.12032
Subject(s) - medicine , mutation , gene , brain abscess , escherichia coli , abscess , microbiology and biotechnology , genetics , surgery , biology
Brain abscesses are uncommon complications of bacterial meningitis or sepsis in neonates and infants. The causative pathogens of brain abscess in newborns are various. Of those, E scherichia coli is rarely seen as a pathogen in brain abscess at this age. Herein we reported brain abscesses in twin infants caused by E . coli sepsis. Interestingly, genetic analysis identified heterozygous T oll‐like receptor 4 ( TLR 4 ) gene mutation in the twins. Because TLR plays an important role in the natural response to bacterial products and initiates specific immune response against these pathogens, this may explain the development of brain abscess in the present case.