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Eruptive agminated nevi in a successfully treated Langerhans cell histiocytosis patient
Author(s) -
Echavarria Maria,
Schoch Jennifer,
Tate Jesalyn,
Motaparthi Kiran,
De Benedetto Anna,
Reith John,
Howell Diane
Publication year - 2021
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/pde.14671
Subject(s) - langerhans cell histiocytosis , medicine , histiocytosis , dermatology , biopsy , pathology , immunohistochemistry , skin biopsy , nevus , melanoma , cancer research , disease
A 7‐year‐old girl with a history of Langerhans cell histiocytosis (LCH), in remission, presented with the sudden appearance of multiple, agminated nevi. Skin biopsy revealed a benign junctional nevus, without recurrence of LCH. Subsequent immunohistochemical testing of both the skin and iliac wing biopsies demonstrated a BRAF V600E mutation. MAPK pathway mutations have been implicated in both LCH and nevogenesis.